| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AKR1B1 | NFAT5 | ENSP00000285930 | ENSP00000396538 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | nuclear factor of activated T-cells 5, tonicity-responsive; Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes | 0.826 |
| AKR1B1 | SLC5A3 | ENSP00000285930 | ENSP00000370543 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.560 |
| AKR1B1 | SLC6A12 | ENSP00000285930 | ENSP00000352702 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation | 0.660 |
| AKR1B1 | UBC | ENSP00000285930 | ENSP00000344818 | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | ubiquitin C | 0.967 |
| CHMP1B | SLC5A3 | ENSP00000432279 | ENSP00000370543 | charged multivesicular body protein 1B; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.856 |
| CHMP1B | UBC | ENSP00000432279 | ENSP00000344818 | charged multivesicular body protein 1B; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | ubiquitin C | 0.898 |
| MIA3 | MRPS6 | ENSP00000340900 | ENSP00000382250 | melanoma inhibitory activity family, member 3 | mitochondrial ribosomal protein S6 | 0.566 |
| MIA3 | SLC5A3 | ENSP00000340900 | ENSP00000370543 | melanoma inhibitory activity family, member 3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.505 |
| MIA3 | UBC | ENSP00000340900 | ENSP00000344818 | melanoma inhibitory activity family, member 3 | ubiquitin C | 0.620 |
| MIA3 | WDR12 | ENSP00000340900 | ENSP00000261015 | melanoma inhibitory activity family, member 3 | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.561 |
| MRPS6 | MIA3 | ENSP00000382250 | ENSP00000340900 | mitochondrial ribosomal protein S6 | melanoma inhibitory activity family, member 3 | 0.566 |
| MRPS6 | SLC5A3 | ENSP00000382250 | ENSP00000370543 | mitochondrial ribosomal protein S6 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.605 |
| MRPS6 | WDR12 | ENSP00000382250 | ENSP00000261015 | mitochondrial ribosomal protein S6 | WD repeat domain 12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome | 0.536 |
| NFAT5 | AKR1B1 | ENSP00000396538 | ENSP00000285930 | nuclear factor of activated T-cells 5, tonicity-responsive; Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.826 |
| NFAT5 | SLC5A3 | ENSP00000396538 | ENSP00000370543 | nuclear factor of activated T-cells 5, tonicity-responsive; Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.481 |
| NFAT5 | SLC6A12 | ENSP00000396538 | ENSP00000352702 | nuclear factor of activated T-cells 5, tonicity-responsive; Plays a role in the inducible expression of genes. Regulates hypertonicity-induced cellular accumulation of osmolytes | solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12; Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation | 0.755 |
| SLC2A13 | SLC5A3 | ENSP00000280871 | ENSP00000370543 | solute carrier family 2 (facilitated glucose transporter), member 13; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | 0.674 |
| SLC2A13 | UBC | ENSP00000280871 | ENSP00000344818 | solute carrier family 2 (facilitated glucose transporter), member 13; H(+)-myo-inositol cotransporter. Can also transport related stereoisomers | ubiquitin C | 0.503 |
| SLC5A3 | AKR1B1 | ENSP00000370543 | ENSP00000285930 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | aldo-keto reductase family 1, member B1 (aldose reductase); Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies | 0.560 |
| SLC5A3 | CHMP1B | ENSP00000370543 | ENSP00000432279 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3; Prevents intracellular accumulation of high concentrations of myo-inositol (an osmolyte) that result in impairment of cellular function | charged multivesicular body protein 1B; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the [...] | 0.856 |
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