WFDC2 protein (Homo sapiens) - STRING network view

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Score

WFDC2

WAP four-disulfide core domain 2 (124 aa)

Predicted Functional Partners:

EGFR

0.820

IPO4

0.810

MSLN

0.720

CES2

0.587

CES5A

0.576

SPP1

0.506

MUC1

0.505

SLPI

0.504

CES1

0.496

LY6G5C

0.483

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CES1	CES2	ENSP00000353720	ENSP00000317842	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	0.959
CES1	CES5A	ENSP00000353720	ENSP00000428864	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.908
CES1	WFDC2	ENSP00000353720	ENSP00000361761	carboxylesterase 1; Has no esterase activity (Probable)	WAP four-disulfide core domain 2	0.496
CES2	CES1	ENSP00000317842	ENSP00000353720	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 1; Has no esterase activity (Probable)	0.959
CES2	CES5A	ENSP00000317842	ENSP00000428864	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.906
CES2	WFDC2	ENSP00000317842	ENSP00000361761	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	WAP four-disulfide core domain 2	0.587
CES5A	CES1	ENSP00000428864	ENSP00000353720	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	carboxylesterase 1; Has no esterase activity (Probable)	0.908
CES5A	CES2	ENSP00000428864	ENSP00000317842	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	0.906
CES5A	WFDC2	ENSP00000428864	ENSP00000361761	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	WAP four-disulfide core domain 2	0.576
EGFR	MUC1	ENSP00000275493	ENSP00000357380	epidermal growth factor receptor	mucin 1, cell surface associated	0.997
EGFR	WFDC2	ENSP00000275493	ENSP00000361761	epidermal growth factor receptor	WAP four-disulfide core domain 2	0.820
IPO4	WFDC2	ENSP00000346453	ENSP00000361761	importin 4; Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis re [...]	WAP four-disulfide core domain 2	0.810
LY6G5C	WFDC2	ENSP00000372724	ENSP00000361761	lymphocyte antigen 6 complex, locus G5C	WAP four-disulfide core domain 2	0.483
MSLN	MUC1	ENSP00000372313	ENSP00000357380	mesothelin	mucin 1, cell surface associated	0.510
MSLN	SPP1	ENSP00000372313	ENSP00000378517	mesothelin	secreted phosphoprotein 1	0.582
MSLN	WFDC2	ENSP00000372313	ENSP00000361761	mesothelin	WAP four-disulfide core domain 2	0.720
MUC1	EGFR	ENSP00000357380	ENSP00000275493	mucin 1, cell surface associated	epidermal growth factor receptor	0.997
MUC1	MSLN	ENSP00000357380	ENSP00000372313	mucin 1, cell surface associated	mesothelin	0.510
MUC1	WFDC2	ENSP00000357380	ENSP00000361761	mucin 1, cell surface associated	WAP four-disulfide core domain 2	0.505
SLPI	WFDC2	ENSP00000342082	ENSP00000361761	secretory leukocyte peptidase inhibitor; Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues	WAP four-disulfide core domain 2	0.504

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