Hras protein (Rattus norvegicus) - STRING network view

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Hras

GTPase HRas GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (189 aa)

Predicted Functional Partners:

Raf1

0.999

Src

0.998

Grb2

0.991

Braf

0.990

Sos2

0.990

Egfr

0.986

Ptpn11

0.985

Rgl1

0.984

Rasgrp3

0.981

Nf1

0.980

Your Current Organism:

Rattus norvegicus

NCBI taxonomy Id: 10116
Other names: Buffalo rat, Gunn rats, Norway rat, R. norvegicus, Rattus, Rattus PC12 clone IS, Rattus norvegicus, Rattus rattiscus, Rattus sp. strain Wistar, Sprague-Dawley rat, Wistar rats, brown rat, laboratory rat, rat, rats, zitter rats

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Braf	Egfr	ENSRNOP00000014604	ENSRNOP00000006087	V-raf murine sarcoma viral oncogene B1-like protein	epidermal growth factor receptor precursor	0.577
Braf	Grb2	ENSRNOP00000014604	ENSRNOP00000005347	V-raf murine sarcoma viral oncogene B1-like protein	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	0.489
Braf	Hras	ENSRNOP00000014604	ENSRNOP00000022363	V-raf murine sarcoma viral oncogene B1-like protein	GTPase HRas GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.990
Braf	Ptpn11	ENSRNOP00000014604	ENSRNOP00000041842	V-raf murine sarcoma viral oncogene B1-like protein	Tyrosine-protein phosphatase non-receptor type 11 ; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (By similarity)	0.426
Braf	Raf1	ENSRNOP00000014604	ENSRNOP00000013831	V-raf murine sarcoma viral oncogene B1-like protein	RAF proto-oncogene serine/threonine-protein kinase ; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kin [...]	0.900
Braf	Rgl1	ENSRNOP00000014604	ENSRNOP00000063014	V-raf murine sarcoma viral oncogene B1-like protein	ral guanine nucleotide dissociation stimulator-like 1	0.490
Braf	Src	ENSRNOP00000014604	ENSRNOP00000012739	V-raf murine sarcoma viral oncogene B1-like protein	proto-oncogene tyrosine-protein kinase Src ; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy b [...]	0.633
Egfr	Braf	ENSRNOP00000006087	ENSRNOP00000014604	epidermal growth factor receptor precursor	V-raf murine sarcoma viral oncogene B1-like protein	0.577
Egfr	Grb2	ENSRNOP00000006087	ENSRNOP00000005347	epidermal growth factor receptor precursor	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	0.999
Egfr	Hras	ENSRNOP00000006087	ENSRNOP00000022363	epidermal growth factor receptor precursor	GTPase HRas GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.986
Egfr	Ptpn11	ENSRNOP00000006087	ENSRNOP00000041842	epidermal growth factor receptor precursor	Tyrosine-protein phosphatase non-receptor type 11 ; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (By similarity)	0.996
Egfr	Raf1	ENSRNOP00000006087	ENSRNOP00000013831	epidermal growth factor receptor precursor	RAF proto-oncogene serine/threonine-protein kinase ; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kin [...]	0.588
Egfr	Rasgrp3	ENSRNOP00000006087	ENSRNOP00000051116	epidermal growth factor receptor precursor	ras guanyl-releasing protein 3	0.656
Egfr	Sos2	ENSRNOP00000006087	ENSRNOP00000006425	epidermal growth factor receptor precursor	son of sevenless homolog 2	0.990
Egfr	Src	ENSRNOP00000006087	ENSRNOP00000012739	epidermal growth factor receptor precursor	proto-oncogene tyrosine-protein kinase Src ; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy b [...]	0.998
Grb2	Braf	ENSRNOP00000005347	ENSRNOP00000014604	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	V-raf murine sarcoma viral oncogene B1-like protein	0.489
Grb2	Egfr	ENSRNOP00000005347	ENSRNOP00000006087	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	epidermal growth factor receptor precursor	0.999
Grb2	Hras	ENSRNOP00000005347	ENSRNOP00000022363	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	GTPase HRas GTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity	0.991
Grb2	Ptpn11	ENSRNOP00000005347	ENSRNOP00000041842	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	Tyrosine-protein phosphatase non-receptor type 11 ; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Dephosphorylates ROCK2 at Tyr-722 resulting in stimulatation of its RhoA binding activity (By similarity)	0.999
Grb2	Raf1	ENSRNOP00000005347	ENSRNOP00000013831	Growth factor receptor-bound protein 2 ; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway (By similarity)	RAF proto-oncogene serine/threonine-protein kinase ; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kin [...]	0.918

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